http://www.psychiatrygrandrounds.com Cutting-edge presentations on clinical neurosciences, behavior, and mental health Sun, 28 Jan 2007 10:00:00 PST en-us Copyright 2007 Ian A Cook MD editor@psychiatrygrandrounds.com wm@psychiatrygrandrounds.com UCLA Semel Institute; Ian A Cook MD, Course Dir. No Psychiatry, Psychiatry Grand Rounds, CME, Mind, Brain, Behavior, Mental Health, psychology, psychopharmacology, therapy Podcast Summary Edition - PsychiatryGrandRounds.com Summaries, interviews, and discussion with leaders in Psychiatry, Neurobiology, Human Behavior, Mental Health, Social Sciences, and Health Care Policy. comments@psychiatrygrandrounds.com Ian A Cook, MD, Course Director Psychiatry Grand Rounds Medicine Ian A Cook MD editor@psychiatrygrandrounds.com Ian A Cook MD Launching our podcast summaries - PsychiatryGrandRounds.com As a complement to our weekly in-person and webcast presentations of Psychiatry Grand Rounds from UCLA's Semel Institute for Neuroscience and Human Behavior, we're now offering summaries via podcasting. Please share your comments with us via email to comments@psychiatrygrandrounds.com http://psychiatrygrandrounds.com/podcast/PsychiatryGR200700.m4a Tue, 02 Jan 2007 22:00:00 PST 1:41 psychiatry, grand rounds, mental health, introduction, UCLA Stephen C Scheiber MD & Ian A Cook MD Update on ABPN Board Certification Stephen Scheiber MD updated us on the current trends in assuring quality via ABPN board certification. http://psychiatrygrandrounds.com/podcast/PsychiatryGR200701.m4a Tue, 09 Jan 2007 22:00:01 PST 2:06 board certification, ABPN, professional, competence, psychiatry, grand rounds, mental health, UCLA Robert Kern PhD & Ian A Cook MD Addressing the disability of schizophrenia through new approaches to learning Dr Robert Kern described work addressing the disability associated with schizophrenia and psychotic illnesses using "errorless learning." This technique circumvents the cognitive deficits in learning, memory, and executive function that commonly contribute to functional disability. http://psychiatrygrandrounds.com/podcast/PsychiatryGR200702.m4a Tue, 23 Jan 2007 22:00:00 PST 3:12 schizophrenia, psychosis, learning, disability, function, executive, frontal lobe, rehabilitation, psychiatry, grand rounds, mental health, UCLA Anthony Lehman MD MSPH & Ian A Cook MD Biological and psychotherapeutic treatments for schizophrenia supported by evidence Dr Lehman updated us on the latest scientific evidence supporting the use of specific biological and psychotherapeutic treatments for patients with schizophrenia and other psychotic disorders (Philip May Memorial Lecture). http://psychiatrygrandrounds.com/podcast/PsychiatryGR200703.m4a Tue, 30 Jan 2007 22:00:00 PST 2:32 evidence, schizophrenia, psychosis, psychiatry, grand rounds, mental health, UCLA Marc A Schuckit MD & Ian A Cook MD Genetic and environmental factors contributng to alcoholism Dr Schuckit described data on the contributions of genetics and the environment to the development of alcoholism. The study of intermediate endophenotypes may help clarify the pathophysiology of alcoholism and identify patient groups that may benefit from different treatments. Research also suggests new possible avenues for prevention. http://psychiatrygrandrounds.com/podcast/PsychiatryGR200704.m4a Tue, 06 Feb 2007 22:00:00 PST 3:31 alcoholism, alcoholic, genetics, endophenotype, psychiatry, grand rounds, mental health, UCLA Stephen Marder MD & Ian A Cook MD Lessons from CATIE and CUtLASS Trials Dr Marder identified key findings and lessons from the CATIE and CUtLASS trials, two large-scale clinical trials in schizophrenia which were supported by the NIMH in the US and the NHS in the UK, respectively. These projects compared clinical outcomes with older and newer antipsychotic medications in treating schizophrenia. Findings call into question what advantages the newer agents may have over older medications. http://psychiatrygrandrounds.com/podcast/PsychiatryGR200705.m4a Tue, 13 Feb 2007 22:00:00 PST 4:37 alcoholism, alcoholic, genetics, endophenotype, psychiatry, grand rounds, mental health, UCLA Michelle Craske PhD & Ian A Cook MD Advances from Translational Research Dr Craske described new fundamental research in learning, memory, attention, and reactivity, and how these advances may be translated into improvements in our cognitive and behavioral treatments for anxiety disorders. http://psychiatrygrandrounds.com/podcast/PsychiatryGR200706.m4a Tue, 27 Feb 2007 22:00:00 PST 2:24 anxiety, cognitive, behavior, behavioral, cbt, psychotherapy, psychology, learning, memory, attention, psychiatry, grand rounds, mental health, UCLA Gary Sachs MD & Ian A Cook MD Key findings to improve care for Bipolar Disorder Dr Sachs updated us on the design and practical findings from the NIMH's STEP-BD project, "Systematic Treatment Enhancement Program for Bipolar Disorder." http://psychiatrygrandrounds.com/podcast/PsychiatryGR200707.m4a Tue, 06 Mar 2007 22:00:01 PST 2:43 bipolar disorder, manic depression, STEP-BD, NIMH, psychiatry, grand rounds, mental health, UCLA Andrew F Leuchter MD, Carole Klove RN JD, & Ian A Cook MD Introducing the new UCLA Guidelines on COI The potential for conflicts of interest to exist has led many Universities to promulgate guidelines and rules to clarify what sorts of behaviors and activities are permissible and which may be construed as unprofessional and corrosive to the relationship of trust between physician and patient. Drs. Andrew Leuchter and Carole Klove address this important topic in this week’s Psychiatry Grand Rounds program, http://psychiatrygrandrounds.com/podcast/PsychiatryGR200708.m4a Tue, 13 Mar 2007 22:00:00 PST 2:49 bipolar disorder, manic depression, STEP-BD, NIMH, psychiatry, grand rounds, mental health, UCLA Peter S Jensen MD & Ian A Cook MD Lessons from the MTA Trial (Multimodal Treatment of ADHD) The NIH conducted the Multimodal Treatment of ADHD, or MTA, Trial to examine outcomes in Attention Deficit Hyperactivity Disorder for children treated by experts with medications, therapy, or the combination, or who received care as usual. Dr. Peter Jensen discussed over a decade of findings from the MTA trial in this week’s Psychiatry Grand Rounds program, http://psychiatrygrandrounds.com/podcast/PsychiatryGR200709.m4a Tue, 20 Mar 2007 22:00:01 PST 2:32 ADD, ADHD, Attention Deficit Hyperactive Disorder, MTA, NIMH, psychiatry, grand rounds, mental health, UCLA Alexander Bystritsky MD PhD & Ian A Cook MD Practical algorithms in treatment resistant anxiety disorders, and research for new interventions A large proportion of patients with anxiety disorders respond well to treatment with SSRI medications and/or Cognitive Behavioral Therapy, but a subset of individuals have treatment-resistant forms of their illness. Dr. Bystritsky is a Professor of Psychiatry at the David Geffen School of Medicine at UCLA and is Director of the Anxiety Disorders Program at the Semel Institute. He updated us on current treatment algorithms and some new interventions for anxiety disorders. http://psychiatrygrandrounds.com/podcast/PsychiatryGR200710.m4a Tue, 27 Mar 2007 22:00:22 PST 2:32 Anxiety, social anxiety, phobia, obsessive compulsive disorder, OCD, panic, psychiatry, grand rounds, mental health, UCLA Mary-Frances O'Connor PhD & Ian A Cook MD Neuroimaging, autonomic, endocrine, and immunologic studies, and their treatment implications The similarities and differences among grief, bereavement, and major depression have constituted an area of considerable attention and debate for many years. Advances in neuroimaging are allowing new work to delineate better these experiences by examining the physiology associated with each. Dr. Mary Frances O'Connor has made this the focus of her research. Dr. O'Connor is a post-doctoral fellow here at UCLA and is the Friends of the Semel Institute Fellow this year. In this week's Psychiatry Grand Rounds program, Dr. O'Connor updates us on current research in this area its clinical implications. http://psychiatrygrandrounds.com/podcast/PsychiatryGR200711.m4a Tue, 03 Apr 2007 22:00:00 PST 3:06 Grief, bereavement, loss, mourning, depression, Friends of the Semel Institute, psychiatry, grand rounds, mental health, UCLA Rita Charon MD PhD & Ian A Cook MD Listening and writing about the interior lives of our patients and ourselves Physicians and other healthcare professionals have a special privilege in knowing our patients in ways outside the ordinary. Patients share with us their stories of struggles with illness, and from this, we are able to know them from a unique perspective. These glimpses of the interior life of our patients invariably impacts on our own lives, yet this is not often acknowledged. Writing about experiences with patients is one way to gain a deeper understanding of these interactions, and a leader in this nascent field of narrative medicine is Dr. Rita Charon. An Internist and Professor of Clinical Medicine, Dr. Charon is Director of the Program in Narrative Medicine at the College of Physicians and Surgeons of Columbia University. Her Psychiatry Grand Rounds program "Narrative Psychiatry: Storied Approaches to Patient Care" introduces us to her approach and suggests ways in which practitioners might adopt some of these techniques into their own practices. http://psychiatrygrandrounds.com/podcast/PsychiatryGR200712.m4a Tue, 10 Apr 2007 22:01:01 PST 2:34 Literature, medicine, narrative, stories, psychiatry, grand rounds, mental health, UCLA Helen Lavretsky MD & Ian A Cook MD Update on the management of late-life depression While major depression is a common psychiatric disorder at any age, depression in late life has some unique features, including differences in the presenting signs and symptoms and in the response to treatment, in comparison with other age groups. The demographic trends associated with aging of the Baby Boom generation suggest that a staggering number of older Americans will develop depression in the coming decades; one of the clear implications is that practitioners will need to be adept at managing depression in older adults. Updating us on new treatment approaches in late-life depression is Dr. Helen Lavretsky. Dr. Lavretsky is an Associate Professor of Psychiatry at the David Geffen School of Medicine at UCLA and a Research Scientist at the Semel Institute. Her Psychiatry Grand Rounds program reviews the setting of late-life depression and presents important new data on the clinical management of depression in older adults. http://psychiatrygrandrounds.com/podcast/PsychiatryGR200713.m4a Tue, 10 Apr 2007 22:02:02 PST 2:00 Depression, late-life, aging, elderly, MDD, psychiatry, grand rounds, mental health, UCLA Murray B Stein MD MPH & Ian A Cook MD Perspectives on genetics and endophenotypes in anxiety disorders Our understanding of anxiety has come a long way from clinical descriptions advanced over the past two centuries. Some advances have come from theories that specific brain regions function together in a neural circuit, and that this circuit may function differently in people with anxiety disorders. The processing of information in such circuits is influenced by a number of so-called susceptibility genes. These genes may lead to what is called a phenotype, such as exhibiting enhanced brain reactivity when seeing a picture of someone who looks frightened. These intermediate phenotypes or "phenes," may identify subsets of individuals within the diagnostic categories in the anxiety disorders. One of the critical thinkers in this area is Dr. Murray Stein. Dr. Stein is a Professor of Psychiatry and of Family and Preventive Medicine at the University of California, San Diego. His Psychiatry Grand Rounds program reviews for us the conceptual approach for understanding complex human behaviors by looking at constituents parts that may have a more clearly-defined neurobiological basis. This has implications for the heritability of anxiety disorders, for understanding the interaction between genes and environment, and for developing new targets for treatments. http://psychiatrygrandrounds.com/podcast/PsychiatryGR200714.m4a Tue, 17 Apr 2007 22:01:01 PST 2:33 Anxiety, phenotype, endophenotype, psychiatry, grand rounds, mental health, UCLA James J Hudziak MD & Ian A Cook MD Review of genetic and environmental factors and resilience vs vulnerability to mental illness In previous decades, the relative roles of genetic and environmental factors were sometimes framed as a debate of "nature vs nurture." Contemporary perspectives find that both sets of factors are important contributors to mental health and illness, and that they interact. Dramatic structural and functional changes occur in the brain as children mature and these changes are influenced by both genes and environment. These changes in turn influence each person's vulnerability or resilience to psychopathology. Many adult psychiatric patients have their first onset of illness in childhood or adolescence, making this of importance not only to child psychiatrists and psychologists, but to mental health practitioners more broadly. This approach is sometimes phrased as "what is inherited is the manner of reaction to a given environment." Important contributions in this area have been made by Dr. James Hudziak. Dr. Hudziak is Director of the Child Psychiatry and Behavioral Genetics program at the University of Vermont. His Psychiatry Grand Rounds program reviews for us this new approach to studying interactions of genes and environment across a wide range of psychiatric illnesses. http://psychiatrygrandrounds.com/podcast/PsychiatryGR200715.m4a Tue, 24 Apr 2007 22:01:01 PST 2:19 Gene, genetics, environment, children, child psychiatry, child psychopathology, psychiatry, grand rounds, mental health, UCLA Susan Bookheimer PhD & Ian A Cook MD New research examining the complexities of Autism Spectrum Disorders Humans are social creatures, and social communications and behaviors help define us. Autism spectrum disorders are marked by problems with social behaviors and by dysregulation in the systems in the brain that support these behaviors. Autism spectrum disorders are defined by three features: 1) delayed language development, 2) poor social skills such as difficulties with joint attention and referencing, and 3) repetitive behaviors, such as hand flapping or rocking. Genetic factors account for much of the prevalence of autism, with perhaps a dozen genes exerting a joint effect. Ultimately, multiple brain systems appear to be involved with autism, and one way to unravel the complexity of the autism spectrum is to use neuroimaging to delineate phenotypes. Imitation of expressions, interest in faces, eye contact, and detecting the emotional content of speech from tone of voice all are areas of study that illuminate the differences between children with autism and typically-developing children. Dr. Susan Bookheimer leads research in this area at UCLA. Dr. Bookheimer is with the Center for Cognitive Neurosciences at UCLA where she is a Professor in the Department of Psychiatry and Biobehavioral Sciences. Her Psychiatry Grand Rounds program reviews for us some new research that uses neuroimaging to understand the neurobiology of autism spectrum disorders. http://psychiatrygrandrounds.com/podcast/PsychiatryGR200716.m4a Tue, 01 May 2007 22:00:10 PST 3:30 Autism, Autism spectrum disorders, fMRI, neuroimaging, communications, social behavior, children, child psychiatry, child psychopathology, psychiatry, grand rounds, mental health, UCLA